Genetic variation in CADM2 as a link between psychological traits and obesity.
Morris J., Bailey MES., Baldassarre D., Cullen B., de Faire U., Ferguson A., Gigante B., Giral P., Goel A., Graham N., Hamsten A., Humphries SE., Johnston KJA., Lyall DM., Lyall LM., Sennblad B., Silveira A., Smit AJ., Tremoli E., Veglia F., Ward J., Watkins H., Smith DJ., Strawbridge RJ.
CADM2 has been associated with a range of behavioural and metabolic traits, including physical activity, risk-taking, educational attainment, alcohol and cannabis use and obesity. Here, we set out to determine whether CADM2 contributes to mechanisms shared between mental and physical health disorders. We assessed genetic variants in the CADM2 locus for association with phenotypes in the UK Biobank, IMPROVE, PROCARDIS and SCARFSHEEP studies, before performing meta-analyses. A wide range of metabolic phenotypes were meta-analysed. Psychological phenotypes analysed in UK Biobank only were major depressive disorder, generalised anxiety disorder, bipolar disorder, neuroticism, mood instability and risk-taking behaviour. In UK Biobank, four, 88 and 172 genetic variants were significantly (p