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We have characterised a cluster of CpG rich (HTF) islands in the alpha-globin complex and report here two unusual features: The human embryonic zeta 2-globin gene is associated with an HTF island within its 3' portion rather than at the 5' end. Furthermore at least two non-functional pseudogenes within the cluster (psi zeta 1 and psi alpha 2) are associated with CpG rich islands.

Original publication

DOI

10.1093/nar/15.22.9215

Type

Journal article

Journal

Nucleic acids research

Publication Date

11/1987

Volume

15

Pages

9215 - 9225

Addresses

Nuffield Department of Clinical Medicine, John Radcliffe Hospital, Headington, Oxford, UK.

Keywords

Animals, Humans, Cytosine, Guanine, DNA Restriction Enzymes, Globins, Guanosine, Dinucleoside Phosphates, Cytidine Monophosphate, Species Specificity, Base Sequence, Genes, Pseudogenes