Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

Plasma for transfusion can be collected through centrifugation of whole blood or by plasma apheresis. It can then be stored frozen as fresh-frozen plasma (FFP) or used to produce more purified constituents, including cryoprecipitate, concentrates of coagulation factors and fibrin sealant, immunoglobulins, anticoagulants, complement related proteins, and albumin. Clinical use of FFP has been maintained over the last two decades in many countries, although the defining characteristic of plasma transfusion is wide variation in transfusion rates. The chapter also discusses the role of plasma transfusion to prevent bleeding (prophylactic) and the use of plasma transfusion in the absence of bleeding to correct abnormal clotting tests. Prothrombin complex concentrates are considered the product of choice in several countries for reversal of warfarin over-anticoagulation in patients who are bleeding or undergo urgent surgery or invasive procedures. Cryoprecipitate is a source of concentrated fibrinogen, and its use is largely focused on patients with clinical bleeding and low-fibrinogen concentrations.

Original publication

DOI

10.1002/9781119719809.ch21

Type

Chapter

Book title

Rossi's Principles of Transfusion Medicine

Publication Date

10/07/2022

Pages

209 - 215