Contact information
Colleges
David Roberts
FMedSci
Professor of Haematology
- Consultant Haematologist
Erythropoiesis / Regulatory T cells in Bone Marrow Transplantation / Malaria Pathogenesis
The current projects in immuno-haematology have been built on our expertise in the study of host-pathogen interactions in malaria by functional and genetic approaches. The unique virulence of falciparum malaria among the species of human parasites appears to be related to the ability of the parasitised erythrocytes to adhere to specific molecules expressed on vascular endothelium. There has therefore been considerable interest in defining the cellular and molecular adhesive phenotypes of malaria infected erythrocytes. In particular it has been suggested that some adhesive phenotypes may be associated with certain syndromes of severe disease for example coma or cerebral malaria. Until recently it has been thought that sequestration of infected erythrocytes in the peripheral circulation enabled these cells to simply avoid passage through and destruction in the spleen. We have studied the functional and pathological significance of the adhesive phenotypes of malaria infected erythrocytes.
Recent publications
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A genome-wide association study of blood cell morphology identifies cellular proteins implicated in disease aetiology.
Journal article
Akbari P. et al, (2023), Nat Commun, 14
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The Relationship Between SARS-CoV-2 Neutralizing Antibody Titers and Avidity in Plasma Collected From Convalescent Nonvaccinated and Vaccinated Blood Donors.
Journal article
Nurmi V. et al, (2023), J Infect Dis, 228, 245 - 250
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Evaluation of interventions to prevent vasovagal reactions among whole blood donors: rationale and design of a large cluster randomised trial.
Journal article
McMahon A. et al, (2023), Trials, 24
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The effect of community water fluoridation on dental caries in children and young people in England: an ecological study.
Journal article
Roberts DJ. et al, (2023), J Public Health (Oxf), 45, 462 - 469
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Accelerated waning of the humoral response to COVID-19 vaccines in obesity.
Journal article
van der Klaauw AA. et al, (2023), Nat Med, 29, 1146 - 1154