Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

The first lineage commitment step of hematopoietic stem cells (HSC) results in separation into distinct lymphoid and myeloid differentiation pathways, reflected in the generation of common lymphoid and myeloid progenitors (CLP and CMP, respectively). In this report we present the first evidence for a nonredundant regulator of this process, in that adult mice deficient in expression of the flt3 ligand (FL) have severely (10-fold) reduced levels of the CLP, accompanied by reductions in the earliest identifiable B and T cell progenitors. In contrast, CMP and HSC are unaffected in FL-deficient mice. Noteworthy, CLP express high levels of both the flt3 receptor and ligand, indicating a potential autocrine role of FL in regulation of the earliest lymphoid commitment step from HSC.

Original publication

DOI

10.1016/s1074-7613(02)00419-3

Type

Journal article

Journal

Immunity

Publication Date

10/2002

Volume

17

Pages

463 - 472

Keywords

Animals, Hematopoietic Stem Cells, Ligands, Lymphopoiesis, Membrane Proteins, Mice, Mice, Inbred C57BL, Mice, Knockout, Myelopoiesis, Phenotype, Recombinant Proteins, Stem Cell Factor