Cookies on this website

We use cookies to ensure that we give you the best experience on our website. If you click 'Accept all cookies' we'll assume that you are happy to receive all cookies and you won't see this message again. If you click 'Reject all non-essential cookies' only necessary cookies providing core functionality such as security, network management, and accessibility will be enabled. Click 'Find out more' for information on how to change your cookie settings.

We have studied the human CD4 T cell response to a functionally conserved domain of Plasmodium falciparum erythrocyte membrane protein-1, cysteine interdomain region-1alpha (CIDR-1alpha). Responses to CIDR-1alpha were striking in that both exposed and nonexposed donors responded. The IFN-gamma response to CIDR-1alpha in the nonexposed donors was partially independent of TCR engagement of MHC class II and peptide. Contrastingly, CD4 T cell and IFN-gamma responses in malaria-exposed donors were MHC class II restricted, suggesting that the CD4 T cell response to CIDR-1alpha in malaria semi-immune adults also has a TCR-mediated component, which may represent a memory response. Dendritic cells isolated from human peripheral blood were activated by CIDR-1alpha to produce IL-12, IL-10, and IL-18. IL-12 was detectable only between 6 and 12 h of culture, whereas the IL-10 continued to increase throughout the 24-h time course. These data strengthen previous observations that P. falciparum interacts directly with human dendritic cells, and suggests that the interaction between CIDR-1alpha and the host cell may be responsible for regulation of the CD4 T cell and cytokine responses to P. falciparum-infected erythrocytes reported previously.

Original publication

DOI

10.4049/jimmunol.176.9.5504

Type

Journal article

Journal

J Immunol

Publication Date

01/05/2006

Volume

176

Pages

5504 - 5512

Keywords

Adult, Animals, Antigens, CD, Antigens, Differentiation, T-Lymphocyte, CD36 Antigens, CD4-Positive T-Lymphocytes, Cell Division, Cells, Cultured, Cysteine, Dendritic Cells, Histocompatibility Antigens Class II, Humans, Interferon-gamma, Killer Cells, Natural, Lectins, C-Type, Malaria, Plasmodium falciparum, Protein Binding, Protozoan Proteins, Receptors, Antigen, T-Cell