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Assessing the association between DNA variants and disease has been used widely to identify regions of the genome and candidate genes that contribute to disease. However, there are numerous examples of associations that cannot be replicated, which has led to skepticism about the utility of the approach for common conditions. With the discovery of massive numbers of genetic markers and the development of better tools for genotyping, association studies will inevitably proliferate. Now is the time to consider critically the design of such studies, to avoid the mistakes of the past and to maximize their potential to identify new components of disease.

Original publication

DOI

10.1038/35052543

Type

Journal article

Journal

Nat Rev Genet

Publication Date

02/2001

Volume

2

Pages

91 - 99

Keywords

Genetic Diseases, Inborn, Humans, Linkage Disequilibrium