Recent Publications

MLL-AF4 Spreading Identifies Binding Sites that Are Distinct from Super-Enhancers and that Govern Sensitivity to DOT1L Inhibition in Leukemia

Posted 20/01/2017

Jon Kerry et al have probed gene regulation in mixed-lineage leukemia (MLL), highlighting a possible biomarker for treatment selection and combination. MLL is a form of leukemia characterised by the translocation of the MLL gene from chromosome 11. This translocation produces over 120 fusion ...

Quantification of Serial Cerebral Blood Flow in Acute Stroke Using Arterial Spin Labeling

Posted 25/11/2016

George Harston et al have employed arterial spin labelling to study cerebral blood flow after an ischaemic stroke. There is a relationship between cerebral blood flow after stroke and the risk of tissue injury. Currently, perfusion weighted MR scans can be used to define which areas of tissue are ...

Modulation of the molecular arrangement in artificial and biological membranes by phospholipid-shelled microbubbles

Posted 10/11/2016

Carugo et al have found that material can be transferred from phospholipid coated microbubbles to cell membranes – with relevance to ultrasound mediated drug discovery. The team employed fluorescence microscopy to reveal that the transfer of phospholipids alters the molecular organisation of the ...

Lone Atrial Fibrillation Is Associated With Impaired Left Ventricular Energetics That Persists Despite Successful Catheter Ablation

Posted 28/10/2016

Rohan Wijesurendra et al have explored left ventricular function in patients with “lone” atrial fibrillation, using a suite of imaging modalities. Atrial fibrillation is the most common form of sustained arrhythmia. It is associated with an increased risk of strokes and heart attack. Lone atrial ...

Initial seeding of the embryonic thymus by immune-restricted lympho-myeloid progenitors

Posted 11/10/2016

TC Luis et al have employed single-cell molecular analysis to probe the intricate mechanisms that lead to T cell development in the thymus. They zeroed in on the initial seeding of the thymus during development and found that the thymopoiesis-initiating progenitors have capacity to develop into ...

Psoriatic T cells recognize neolipid antigens generated by mast cell phospholipase delivered by exosomes and presented by CD1a

Posted 30/09/2016

Ka Lun Cheung et al have revealed new mechanisms that drive psoriasis, highlighting possible avenues for treatment development. Psoriasis is a chronic inflammatory skin disease, characterised by the infiltration of immune cells including T helper 17 cells. The team found that PLA2-responsive ...

Multi-modal assessment of neurovascular coupling during cerebral ischaemia and reperfusion using remote middle cerebral artery occlusion

Posted 16/09/2016

B Sutherland et al have developed a new way to build a detailed picture of neurovascular coupling during cerebral ischaemia and reperfusion. Neurovascular coupling is the mechanism that regulates blood flow to the brain and it is disrupted during cerebral ischaemia and reperfusion (as occurs in ...

Stakeholder views on secondary findings in whole-genome and whole-exome sequencing: a systematic review of quantitative and qualitative studies

Posted 02/09/2016

Michael Mackley et al, have carried out a systematic review of studies that delve into secondary findings in whole genome and whole exome sequencing. While WGS/WES are fantastic tools for research and ever more so in clinical practice, they can also reveal information that isn’t relevant to the ...

Assessment of Metformin Induced Changes in Cardiac and Hepatic Redox State Using Hyperpolarized [1-13C]Pyruvate

Posted 30/08/2016

AJ Lewis et al have used Hyperpolarized [1-13C] Pyruvate magnetic resonance spectroscopy to probe the impact of metformin on the heart. Metformin is widely prescribed to people with type 2 diabetes. The drug appears to improve cardiovascular outcomes in people living with type 2 diabetes, but ...

Systematic Functional Characterization of Candidate Causal Genes for Type 2 Diabetes Risk Variants

Posted 25/08/2016

Soren Thomsen et al have generated a novel genetic screen to look for genes involved in the causes of type 2 diabetes. They used a new human β-cell line – EndoC-βh1 – to perform and validate an siRNA screen, using insulin secretion is response to varying levels of glucose as a read-out. Using this ...