DPhil Projects

A wide variety of doctoral projects are available for students applying for either a DPhil in Cardiovascular Medicine or the DPhil in Medical Sciences in the Radcliffe Department of Medicine. These projects are open to students on funded programmes (detailed on the Funding page) and to direct applicants.

The list below shows projects available for entry in October 2014. Please note that at this stage of the admissions cycle some projects will already have recruited or the PI may no longer be able to accept anymore students into the lab. Please contact the prospective supervisor to check that a project/lab space is available prior to submitting your application. If you are particularly interested in working with a specific PI and no project is listed, please contact them directly to enquire as to whether they will be offering projects or accepting students in October 2014.

Additional DPhil projects are available in the Nuffield Department of Clinical Medicine, particularly in immunology.

Filter by theme:
DPhil Project Project Supervisors Theme
A new way to control infections? (reference number 500) Drakesmith, Alexander (Hal)
  • Immunology
Airway Gene Therapy for Cystic Fibrosis (reference number 567) Gill, Deborah Hyde, Stephen
  • Genes, Genetics, Epigenetics & Genomics
  • Translational Medicine & Medical Technology
Airway Gene Transfer to Create Lung Protein Factories (reference number 568) Gill, Deborah Hyde, Stephen
  • Translational Medicine & Medical Technology
  • Genes, Genetics, Epigenetics & Genomics
An investigation of the clinical utility of a gene-expression profiling-based signature in the myelodysplastic syndromes (reference number 558) Boultwood, Jacqueline Pellagatti, Andrea
  • Genes, Genetics, Epigenetics & Genomics
An investigation of the role of mutations in the spliceosome machinery in the myelodysplastic syndromes (reference number 557) Boultwood, Jacqueline Pellagatti, Andrea
  • Genes, Genetics, Epigenetics & Genomics
Analysis of lipid and lipid-anchored protein organization at the T-cell surface using novel super-resolution (STED-FCS) microscopy (reference number 515) Eggeling, Christian Davis, Simon
  • Immunology
Analysis of lipid-antigen assisted T-cell activation using live-cell super-resolution (STED) microscopy (reference number 514) Eggeling, Christian Cerundolo, Vincenzo
  • Immunology
Antibody Gene Transfer To The Lung To Prevent Emerging Pulmonary Infections (reference number 569) Hyde, Stephen Gill, Deborah
  • Translational Medicine & Medical Technology
  • Genes, Genetics, Epigenetics & Genomics
Augmentation of cardiac energetics in transgenic models (reference number 554) Lygate, Craig Neubauer, Stefan
  • Cardiovascular Science
Blood pressure lowering and risk of cause-specific morbidity and mortality (reference number 574) Rahimi, Kazem Woodward, Mark MacMahon, Stephen
  • Evidence-based Practice, Epidemiology & Health
  • Cardiovascular Science
BMP-signalling and cardiac fibrosis (reference number 539) Bhattacharya, Shoumo
  • Molecular, Cell & Systems Biology
  • Cardiovascular Science
Cancer therapeutics based on antibody fragments (reference number 549) Rabbitts, Terence
  • Cancer
Cardiac regeneration in zebrafish (reference number 534) Patient, Roger
  • Developmental Biology & Stem Cells
  • Cardiovascular Science
Cardiovascular imaging in preventive research (reference number 507) Leeson, Paul
  • Cardiovascular Science
CELLULAR REPROGRAMMING USING RNA-BASED LOGIC FUNCTION MOLECULAR DEVICES (reference number 552) Fulga, Tudor
  • Molecular, Cell & Systems Biology
  • Genes, Genetics, Epigenetics & Genomics
Characterisation of aberrant self-renewal pathways in Leukaemic Stem Cells in Acute Myeloid Leukaemia (AML) (reference number 524) Vyas, Paresh
  • Haematology
  • Cancer
Characterising the Myocardium using MRI (reference number 523) Robson, Matthew
  • Cardiovascular Science
  • Translational Medicine & Medical Technology
Characterization of perivascular adipose tissue by non-invasive imaging in experimental animal models and humans (reference number 561) Antoniades, Charalambos Schneider, Jurgen
  • Cardiovascular Science
  • Translational Medicine & Medical Technology
Chromatin remodeling and gene expression (reference number 527) Gibbons, Richard Higgs, Doug
  • Genes, Genetics, Epigenetics & Genomics
  • Developmental Biology & Stem Cells
Chromatin remodeling and genome stability (reference number 528) Gibbons, Richard Higgs, Doug
  • Genes, Genetics, Epigenetics & Genomics
Controlling malaria through manipulating iron availability to Plasmodium (reference number 499) Drakesmith, Alexander (Hal)
  • Immunology
Critical players downstream of Runx1/AML1 in hematopoietic stem cell generation (reference number 532) de Bruijn, Marella Patient, Roger
  • Developmental Biology & Stem Cells
  • Molecular, Cell & Systems Biology
Cyclic peptide inhibitors of TGFbeta signalling (reference number 548) Bhattacharya, Shoumo
  • Molecular, Cell & Systems Biology
  • Cardiovascular Science
Development of Contrast Agents for Molecular Imaging of Hypoxia in the Heart (reference number 520) Schneider, Jurgen Davis, Ben and Lygate, Craig
  • Translational Medicine & Medical Technology
  • Cardiovascular Science
Development of Gene Therapy for Lung Disorders (reference number 570) Hyde, Stephen Gill, Deborah
  • Translational Medicine & Medical Technology
  • Genes, Genetics, Epigenetics & Genomics
Development of tools and techniques for a non-invasive quantification of atheromatic plaque burden in small animal models in vivo using intrinsic contrast and molecular imaging (reference number 560) Schneider, Jurgen Antoniades, Charalambos
  • Cardiovascular Science
Dissecting heterogeneity in GWAS (reference number 508) Farrall, Martin
  • Bioinformatics, Statistics & Computational Biology
  • Genes, Genetics, Epigenetics & Genomics
Dissecting the genetic interaction between SCL and RUNX1 during blood stem cell development (reference number 566) Porcher, Catherine de Bruijn, Marella
  • Developmental Biology & Stem Cells
  • Molecular, Cell & Systems Biology
Dissecting the role of SAMHD1 in B-cell chronic lymphocytic leukemia (reference number 542) Rehwinkel, Jan Schuh, Anna
  • Haematology
  • Immunology
Effect of a local islet DPP-IV system on human pancreatic hormone secretion: elucidating its role and mechanism of action. (reference number 556) Ramracheya, Reshma Clark, Anne and Rorsman, Patrik
  • Diabetes, Endocrinology & Metabolism
  • Translational Medicine & Medical Technology
Epigenetic programming of hematopoietic stem cells and their progeny. (reference number 551) Nerlov, Claus Higgs, Doug Jacobsen, Sten Eirik
  • Developmental Biology & Stem Cells
  • Haematology
Exome sequencing to identify new disease genes for hypertrophic cardiomyopathy (reference number 511) Watkins, Hugh
  • Genes, Genetics, Epigenetics & Genomics
  • Cardiovascular Science
Exome sequencing to identify new genetic causes of craniosynostosis (reference number 509) Wilkie, Andrew
  • Genes, Genetics, Epigenetics & Genomics
  • Bioinformatics, Statistics & Computational Biology
Exploring a new cross-talk between adipose tissue and the vascular wall (reference number 516) Antoniades, Charalambos
  • Cardiovascular Science
  • Diabetes, Endocrinology & Metabolism
Exploring the therapeutic potential of homoarginine supplementation in cardiovascular disease (reference number 555) Lygate, Craig Neubauer, Stefan
  • Cardiovascular Science
Functional genomic analysis of genetic susceptibility loci for coronary artery disease (reference number 512) Watkins, Hugh
  • Genes, Genetics, Epigenetics & Genomics
  • Cardiovascular Science
GATA3 Regulation Of The Parathyroid Developmental Pathway (reference number 490) Thakker, Rajesh
  • Diabetes, Endocrinology & Metabolism
  • Molecular, Cell & Systems Biology
Gene regulatory networks underlying mammalian blood stem cell generation (reference number 531) de Bruijn, Marella
  • Developmental Biology & Stem Cells
  • Molecular, Cell & Systems Biology
Gene Therapy for Endocrine Tumours (reference number 503) Thakker, Rajesh
  • Diabetes, Endocrinology & Metabolism
  • Molecular, Cell & Systems Biology
Human cardiac imaging at 7Tesla (reference number 522) Robson, Matthew
  • Cardiovascular Science
  • Translational Medicine & Medical Technology
Investigating mechanisms by which antigen presenting cells enter and migrate within lymphatic vessels for immune surveillance (reference number 537) Jackson, David
  • Immunology
  • Molecular, Cell & Systems Biology
IT-supported risk prediction and decision support algorithms for management of heart failure in the community (reference number 573) Rahimi, Kazem Woodward, Mark Khorshidi, Reza
  • Bioinformatics, Statistics & Computational Biology
  • Evidence-based Practice, Epidemiology & Health
Loss of fumarate hydratase in a novel model of diabetes - a metabolic link with cancer (reference number 519) Ramracheya, Reshma
  • Diabetes, Endocrinology & Metabolism
  • Cancer
Low frequency DNA variants and their contribution to individual predisposition to type 2 diabetes (reference number 505) McCarthy, Mark
  • Genes, Genetics, Epigenetics & Genomics
  • Diabetes, Endocrinology & Metabolism
Mechanisms of vein graft failure in coronary bypass surgery (reference number 517) Antoniades, Charalambos
  • Cardiovascular Science
MICRORNA-MEDIATED TRANSCRIPTIONAL REGULATION OF EMT IN NEURAL CREST AND CANCER (reference number 526) Sauka-Spengler, Tatjana
  • Genes, Genetics, Epigenetics & Genomics
  • Cancer
miRNA-MEDIATED REGULATION OF AXONAL STRUCTURAL INTEGRITY AND NERVE INJURY RESPONSE (reference number 553) Fulga, Tudor
  • Molecular, Cell & Systems Biology
  • Developmental Biology & Stem Cells
Molecular mechanisms of haemopoietic stem cell aging (reference number 543) Nerlov, Claus Jacobsen, Sten Eirik
  • Haematology
  • Developmental Biology & Stem Cells
Molecular Mechanisms of Parathyroid Gland Development (reference number 493) Thakker, Rajesh
  • Diabetes, Endocrinology & Metabolism
  • Molecular, Cell & Systems Biology
Molecular-dynamic correlates of oxidant haemolysis in glucose-6-phosphate dehydrogenase (G6PD) deficiency (reference number 126) White, Nicholas and Day, Nicholas and Nosten, François and Weatherall, David
Multi-parametric image analysis to facilitate the CMR one-stop shop (reference number 521) Schneider, Jurgen Grau, Vicente
  • Translational Medicine & Medical Technology
  • Cardiovascular Science
Mysterious metabolic regulation of glucagon secretion (reference number 529) Rorsman, Patrik Tarasov, Andrei
  • Diabetes, Endocrinology & Metabolism
  • Molecular, Cell & Systems Biology
Novel Multicolour Super-Resolution Microscopy of the Living Cell (reference number 453) Padilla-Parra, Sergi and Eggeling, Christian
Prevention of cardiovascular disease in mother and child following preeclampsia (reference number 506) Leeson, Paul
  • Cardiovascular Science
Production of a novel live attenuated flu vaccine that would be appropriate for pre-pandemic intranasal immunisation. (reference number 501) Townsend, Alain
  • Immunology
Production of therapeutic human monoclonal antibodies to influenza A and B. (reference number 502) Townsend, Alain
  • Immunology
Programming blood stem cells during embryonic development (reference number 533) Patient, Roger
  • Developmental Biology & Stem Cells
  • Haematology
Road Map of Normal Human Haemopoiesis (reference number 525) Vyas, Paresh
  • Haematology
  • Developmental Biology & Stem Cells
Role of CD1a-restricted T cells in human inflammation and translational development of new therapies to treat allergic disease (reference number 495) Ogg, Graham
  • Immunology
  • Translational Medicine & Medical Technology
Role of Innate Lymphoid Cells in skin inflammation (reference number 545) Ogg, Graham
  • Immunology
  • Translational Medicine & Medical Technology
Role of miR on atrial electrical remodelling in atrial fibrillation (reference number 550) Casadei, Barbara Reilly, Svetlana
  • Cardiovascular Science
  • Translational Medicine & Medical Technology
Selfish Selection in the Human Testis (reference number 510) Wilkie, Andrew
  • Genes, Genetics, Epigenetics & Genomics
  • Bioinformatics, Statistics & Computational Biology
Single Cell Analysis of Malignant Stem Cells in Myeloid Malignancies (reference number 565) Mead, Adam Jacobsen, Sten Eirik
  • Molecular, Cell & Systems Biology
  • Haematology
Sodium channels, chronic pain and insulin secretion (reference number 559) Rorsman, Patrik Chibalina, Margareta Hastoy, Benoit
  • Diabetes, Endocrinology & Metabolism
Structural Dissection of a Leukemia Oncogene Multi-Protein Transcription Factor Complex (reference number 109) Mancini, Erika and Porcher, Catherine
Studies of vesicle trafficking and endocytosis: using Dent's disease due to CLC-5 mutations as a model (Kidney Research UK) (reference number 571) Thakker, Rajesh Piret, Sian
  • Molecular, Cell & Systems Biology
  • Diabetes, Endocrinology & Metabolism
The bone morphogenetic protein pathway in immunity (reference number 498) Drakesmith, Alexander (Hal)
  • Immunology
The dynamics of activating and inhibitory NK cell receptors at the cell-surface (reference number 459) Gillespie, Geraldine and Eggeling, Christian
The impact of HIV on HCV immunity in a cohort of HIV/HCV co-infected patients (reference number 443) Dong, Tao
  • Immunology
The impact of IFTIM3 genetic variation on Influenza virus infection, immune responses and disease outcome (reference number 547) Dong, Tao McMichael, Andrew
  • Immunology
  • Molecular, Cell & Systems Biology
The metabolic regulation of glucagon secretion (Diabetes UK studentship) (reference number 572) Rorsman, Patrik Tarasov, Andrei
  • Diabetes, Endocrinology & Metabolism
  • Molecular, Cell & Systems Biology
The role of ceramide synthesis in human adipocytes for cellular turnover and inflammation signalling (reference number 562) Karpe, Fredrik
  • Diabetes, Endocrinology & Metabolism
Tracking blood stem cell development from Embryonic Stem (ES) cells (reference number 564) Porcher, Catherine Patient, Roger
  • Developmental Biology & Stem Cells
  • Molecular, Cell & Systems Biology
Transcriptional control of blood development: mechanisms of action of a key regulator in cell fate decisions (reference number 513) Porcher, Catherine
  • Developmental Biology & Stem Cells
  • Molecular, Cell & Systems Biology
Translating Genetic Association Signals into Molecular Mechanisms for Type 2 Diabetes (reference number 504) Gloyn, Anna
  • Genes, Genetics, Epigenetics & Genomics
  • Diabetes, Endocrinology & Metabolism
Understanding the effect of tissue specific de novo lipogenesis on hepatic and adipose tissue fatty acid metabolism. (reference number 563) Hodson, Leanne
  • Diabetes, Endocrinology & Metabolism