A wide variety of doctoral projects are available for students applying for either a DPhil in Cardiovascular Medicine or the DPhil in Medical Sciences in the Radcliffe Department of Medicine. These projects are open to students on funded programmes (detailed on the Funding page) and to direct applicants.
| DPhil Project |
Principal Investigator |
Theme |
|
A new way to control infections?
(reference number 28)
|
Drakesmith, Alexander
|
|
|
Airway specific pseudotyping of lentiviral vectors – engineering the ultimate lung gene therapy vector
(reference number 43)
|
Hyde, Stephen
|
- Translational Medicine & Medical Technology
- Genes, Genetics, Epigenetics & Genomics
|
|
An investigation of the role of mutations in the spliceosome machinery in the myelodysplastic syndromes
(reference number 58)
|
Boultwood, Jacqueline
|
- Genes, Genetics, Epigenetics & Genomics
- Cancer
|
|
Analysis of lipid and lipid-anchored protein organization at the T-cell surface using novel super-resolution (STED-FCS) microscopy
(reference number 52)
|
Eggeling, Christian
|
|
|
Analysis of lipid-antigen assisted T-cell activation using live-cell super-resolution (STED) microscopy
(reference number 50)
|
Eggeling, Christian
|
|
|
Cardiac regeneration in zebrafish
(reference number 89)
|
Patient, Roger
|
- Developmental Biology & Stem Cells
- Cardiovascular Science
|
|
Cardiovascular imaging in preventive research
(reference number 35)
|
Leeson, Paul
|
|
|
CG dinucleotide involvement in effective repeated airway administration of Lentiviral vectors to the lung
(reference number 42)
|
Gill, Deborah
|
- Genes, Genetics, Epigenetics & Genomics
- Translational Medicine & Medical Technology
|
|
Characterisation of aberrant self-renewal pathways in Leukaemic Stem Cells in Acute Myeloid Leukaemia (AML)
(reference number 75)
|
Vyas, Paresh
|
|
|
Characterisation of Candidate founder mutations in Chronic lymphocytic leukaemia (CLL)
(reference number 96)
|
Schuh, Anna
|
- Haematology
- Translational Medicine & Medical Technology
|
|
Characterisation of the mechanisms by which tumours can hamper cancer specific immune responses
(reference number 82)
|
Cerundolo, Vincenzo
|
|
|
Characterising the Myocardium using MRI
(reference number 71)
|
Robson, Matthew
|
- Cardiovascular Science
- Translational Medicine & Medical Technology
|
|
Chromatin remodeling and gene expression
(reference number 79)
|
Gibbons, Richard
|
- Genes, Genetics, Epigenetics & Genomics
- Developmental Biology & Stem Cells
|
|
Chromatin remodeling and genome stability
(reference number 80)
|
Gibbons, Richard
|
- Genes, Genetics, Epigenetics & Genomics
|
|
Clinical Lentiviral vector design and production
(reference number 41)
|
Hyde, Stephen
|
- Translational Medicine & Medical Technology
- Genes, Genetics, Epigenetics & Genomics
|
|
Control of breast cancer cellular phenotype by the forkhead transcription factor FOXP1
(reference number 61)
|
Banham, Alison
|
- Cancer
- Molecular, Cell & Systems Biology
|
|
Controlling malaria through manipulating iron availability to Plasmodium
(reference number 27)
|
Drakesmith, Alexander
|
|
|
Critical players downstream of Runx1/AML1 in hematopoietic stem cell generation
(reference number 87)
|
de Bruijn, Marella
|
- Developmental Biology & Stem Cells
- Molecular, Cell & Systems Biology
|
|
DECIPHIRING THE ROLE OF NON-CODING RNAs IN CANCER
(reference number 65)
|
Fulga, Tudor
|
- Cancer
- Genes, Genetics, Epigenetics & Genomics
|
|
Determinants of the intrinsic gluteofemoral adipose tissue characteristics
(reference number 1)
|
Karpe, Fredrik
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
Development of 1H-Magnetic Resonance Spectroscopic Imaging Techniques in the Mouse Heart
(reference number 68)
|
Schneider, Jurgen
|
- Translational Medicine & Medical Technology
- Cardiovascular Science
|
|
Development of Contrast Agents for Molecular Imaging of Hypoxia in the Heart
(reference number 67)
|
Schneider, Jurgen
|
- Translational Medicine & Medical Technology
- Cardiovascular Science
|
|
Development of plasmid DNA-based mucosal vaccines.
(reference number 44)
|
Gill, Deborah
|
- Genes, Genetics, Epigenetics & Genomics
- Translational Medicine & Medical Technology
|
|
Dissecting heterogeneity in genetic associations
(reference number 36)
|
Farrall, Martin
|
- Bioinformatics, Statistics & Computational Biology
- Genes, Genetics, Epigenetics & Genomics
|
|
Dissecting the role of SAMHD1 in B-cell chronic lymphocytic leukemia
(reference number 100)
|
Rehwinkel, Jan
|
|
|
Effects of glucagon-like peptide–1 (GLP-1) amides on insulin and glucagon secretion in human islets: is a ‘novel’ GLP-1 receptor involved?
(reference number 72)
|
Ramracheya, Reshma
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
Evaluation of statistical techniques to inform a risk-based approach to clinical trial monitoring
(reference number 97)
|
Bethel, Angelyn
|
- Evidence-based Practice, Epidemiology & Health
- Diabetes, Endocrinology & Metabolism
|
|
Exome sequencing to identify new disease genes for hypertrophic cardiomyopathy
(reference number 45)
|
Watkins, Hugh
|
- Genes, Genetics, Epigenetics & Genomics
- Cardiovascular Science
|
|
Exome sequencing to identify new genetic causes of craniosynostosis
(reference number 37)
|
Wilkie, Andrew
|
- Genes, Genetics, Epigenetics & Genomics
- Bioinformatics, Statistics & Computational Biology
|
|
Exploring the interaction between adipose tissue and the vascular wall in humans
(reference number 56)
|
Antoniades, Charalambos
|
- Cardiovascular Science
- Diabetes, Endocrinology & Metabolism
|
|
Factors regulating the cellular inflammatory response in myocardial infarction
(reference number 90)
|
Choudhury, Robin
|
|
|
Finding the determines for efficient viral control by cytotoxic T cell responses
(reference number 48)
|
Dong, Tao
|
- Immunology
- Molecular, Cell & Systems Biology
|
|
Functional analysis of how diabetes genes affect β-cell function
(reference number 2)
|
Rorsman, Patrik
|
- Diabetes, Endocrinology & Metabolism
|
|
Functional genomic analysis of genetic susceptibility loci for coronary artery disease
(reference number 46)
|
Watkins, Hugh
|
- Genes, Genetics, Epigenetics & Genomics
- Cardiovascular Science
|
|
GATA3 Regulation Of The Parathyroid Developmental Pathway
(reference number 3)
|
Thakker, Rajesh
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
Gene regulatory networks underlying mammalian blood stem cell generation
(reference number 86)
|
de Bruijn, Marella
|
- Developmental Biology & Stem Cells
- Molecular, Cell & Systems Biology
|
|
Gene Therapy for Endocrine Tumours
(reference number 31)
|
Thakker, Rajesh
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
HCV specific T cell responses in Chronic HCV infection: Friends or foe?
(reference number 49)
|
Dong, Tao
|
|
|
How to evade the immune system: varicella zoster virus
(reference number 24)
|
Ogg, Graham
|
- Immunology
- Translational Medicine & Medical Technology
|
|
Human cardiac imaging at 7Tesla
(reference number 70)
|
Robson, Matthew
|
- Cardiovascular Science
- Translational Medicine & Medical Technology
|
|
Imaging the distribution and kinetics of virus detection by innate immune receptors with super-resolution STED microscopy
(reference number 51)
|
Eggeling, Christian
|
|
|
Investigating structure and function of the lymphatic endothelial receptor LYVE-1, an important regulator of leukocyte trafficking.
(reference number 92)
|
Jackson, David
|
|
|
Lipid Specific T cells in health and disease
(reference number 83)
|
Cerundolo, Vincenzo
|
|
|
Loss of fumarate hydratase in a novel model of diabetes - a metabolic link with cancer
(reference number 64)
|
Ramracheya, Reshma
|
- Diabetes, Endocrinology & Metabolism
- Cancer
|
|
Low frequency DNA variants and their contribution to individual predisposition to type 2 diabetes
(reference number 33)
|
McCarthy, Mark
|
- Genes, Genetics, Epigenetics & Genomics
- Diabetes, Endocrinology & Metabolism
|
|
Mechanisms of leukocyte trafficking via lymphatics in inflammation
(reference number 93)
|
Jackson, David
|
|
|
Mechanisms of tumour metastasis via the lymphatic vessels
(reference number 94)
|
Jackson, David
|
|
|
Mechanisms of vein graft failure in coronary bypass surgery
(reference number 57)
|
Antoniades, Charalambos
|
|
|
Mesenchymal Stem Cells in the Stem Cell Niche
(reference number 85)
|
Watt, Suzanne
|
- Developmental Biology & Stem Cells
- Molecular, Cell & Systems Biology
|
|
MicroRNA regulation of PTEN in human adipose tissue
(reference number 7)
|
Karpe, Fredrik
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
microRNA-MEDIATED TRANSCRIPTIONAL REGULATION IN ALZHEIMER DISEASE
(reference number 66)
|
Fulga, Tudor
|
- Ageing, Geratology & Degenerative Diseases
- Genes, Genetics, Epigenetics & Genomics
|
|
MicroRNA-mediated Transcriptional Regulation of EMT in Neural Crest and Cancer
(reference number 78)
|
Sauka-Spengler, Tatjana
|
- Genes, Genetics, Epigenetics & Genomics
- Cancer
|
|
Molecular and epigenetic mechanisms leukaemia
(reference number 99)
|
Milne, Thomas
|
- Cancer
- Molecular, Cell & Systems Biology
|
|
Molecular mechanisms of haemopoietic stem cell aging
(reference number 102)
|
Nerlov, Claus
|
- Haematology
- Developmental Biology & Stem Cells
|
|
Molecular Mechanisms of Parathyroid Gland Development
(reference number 8)
|
Thakker, Rajesh
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
Multi-parametric image analysis to facilitate the CMR one-stop shop
(reference number 69)
|
Schneider, Jurgen
|
- Translational Medicine & Medical Technology
- Cardiovascular Science
|
|
New ways to think about treating autoimmunity
(reference number 98)
|
Davis, Simon
|
- Immunology
- Translational Medicine & Medical Technology
|
|
Noncanonical Notch ligands: what do they do in cancers?
(reference number 59)
|
Banham, Alison
|
- Cancer
- Molecular, Cell & Systems Biology
|
|
Phosphoproteome analysis of Dengue or Influenza virus stimulated dendritic cells
(reference number 81)
|
Luhn, Kerstin
|
- Immunology
- Microbiology, Infection & Tropical Medicine
|
|
Post-transcriptional regulation of the forkhead transcription factor FOXP1 by tumour microRNAs
(reference number 62)
|
Banham, Alison
|
|
|
Prevention of cardiovascular disease in mother and child following preeclampsia
(reference number 34)
|
Leeson, Paul
|
|
|
Production of a novel live attenuated flu vaccine that would be appropriate for pre-pandemic intranasal immunisation.
(reference number 29)
|
Townsend, Alain
|
|
|
Production of therapeutic human monoclonal antibodies to influenza A and B.
(reference number 30)
|
Townsend, Alain
|
|
|
Programming blood stem cells during embryonic development
(reference number 88)
|
Patient, Roger
|
- Developmental Biology & Stem Cells
- Haematology
|
|
Regulation of glucagon secretion: physiology and pathophysiology
(reference number 84)
|
Rorsman, Patrik
|
- Diabetes, Endocrinology & Metabolism
- Molecular, Cell & Systems Biology
|
|
Road Map of Normal Human Haemopoiesis
(reference number 76)
|
Vyas, Paresh
|
- Haematology
- Developmental Biology & Stem Cells
|
|
Role of CD1a-restricted T cells in human inflammation and translational development of new therapies to treat allergic disease
(reference number 22)
|
Ogg, Graham
|
- Immunology
- Translational Medicine & Medical Technology
|
|
Role of inflammation and microvascular coronary dysfunction in patients with atrial fibrillation
(reference number 73)
|
Casadei, Barbara
|
- Cardiovascular Science
- Translational Medicine & Medical Technology
|
|
Role of inflammation and oxidative stress in AF inducibility and atrial electrical remodelling in mice
(reference number 74)
|
Casadei, Barbara
|
- Cardiovascular Science
- Molecular, Cell & Systems Biology
|
|
Role of lincRNAs in Regulatory Circuitry Controlling Neural Crest Stem Cell-like potential
(reference number 77)
|
Sauka-Spengler, Tatjana
|
- Genes, Genetics, Epigenetics & Genomics
- Developmental Biology & Stem Cells
|
|
Selfish Selection in the Human Testis
(reference number 38)
|
Wilkie, Andrew
|
- Genes, Genetics, Epigenetics & Genomics
- Bioinformatics, Statistics & Computational Biology
|
|
Subcellular localisation of Dengue virus and its impact on disease severity
(reference number 53)
|
Luhn, Kerstin
|
- Immunology
- Microbiology, Infection & Tropical Medicine
|
|
Super-resolution imaging of early signalling events in T cells
(reference number 60)
|
Davis, Simon
|
- Immunology
- Molecular, Cell & Systems Biology
|
|
T cell mediated immune response in HBV associated liver disease
(reference number 55)
|
Dong, Tao
|
|
|
The bone morphogenetic protein pathway in immunity
(reference number 26)
|
Drakesmith, Alexander
|
|
|
The impact of the inflammasome in Dengue infection
(reference number 54)
|
Luhn, Kerstin
|
- Immunology
- Microbiology, Infection & Tropical Medicine
|
|
The role of EZH2 in normal and malignant haematopoiesis
(reference number 101)
|
Mead, Adam
|
- Haematology
- Molecular, Cell & Systems Biology
|
|
The role of fructose in diabetic dyslipidaemia.
(reference number 63)
|
Hodson, Leanne
|
- Diabetes, Endocrinology & Metabolism
|
|
Therapeutic target identification in the BMP-signalling pathway using cell-based assays.
(reference number 95)
|
Bhattacharya, Shoumo
|
- Cardiovascular Science
- Molecular, Cell & Systems Biology
|
|
Transcriptional regulation of blood stem cell development
(reference number 47)
|
Porcher, Catherine
|
- Developmental Biology & Stem Cells
- Molecular, Cell & Systems Biology
|
|
Translating Genetic Association Signals into Molecular Mechanisms for Type 2 Diabetes
(reference number 32)
|
Gloyn, Anna
|
- Genes, Genetics, Epigenetics & Genomics
- Diabetes, Endocrinology & Metabolism
|
|
Virus sensing by the innate immune receptor MDA5
(reference number 40)
|
Rehwinkel, Jan
|
|
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